.Pathologically: It is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role especially mast cells, eosinophils and T-lymphocytes resulting in airflow obstruction due to combination of smooth muscle contraction, mucosal edema, inflammation and viscid mucus secretions.
.Clinically: The chronic inflammation is associated with airway hyperresponsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the early morning.
.Prognostically: These episodes are usually associated with widespread, but variable, airflow obstruction within the lung that is often reversible either spontaneously or with treatment.
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