Occupational Lung diseases

-Classification:

	Causes	Mechanism
Upper RT irritation	-Irritant gases -Solvents	Mucosal irritation
Airway disorders	-Occupational asthma -Byscinosis -Emphysema (coal) -Ch. Bronchitis (mineral & grain dust)	-Mast cell mediators -Endotoxins & complement activation -Neutrophil enzymes -Mucosal irritation
Acute inhalational injury	-Toxic pneumonitis (gases & metals) -Metal fume fever (Zn, Cu oxides) -Polymer fume fever (plastic) -Smoke inhalation (combustion)	Mucosal irritation (by diffusion)
Hypersensitivity pneumonitis	-Bacteria -Fungi -Animal proteins	Type 3 and 4 hypersensitivity reactions
Infectious disorders	-TB -Viruses -Bacteria	---------
Pneumoconiosis	-Asbestosis -Silicosis -CWP -Berryliosis -Cobalt exposure	MQ damage & type 4 hypersensitivity reaction (in diffuse types)
Malignancies	-Mesothelioma (asbestos, radon) -Sino-nasal cancer (wood dust)	DNA damage

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